Supplementary Figure 1: Annotation of active cis-regulatory elements in distinct brain regions.
From: Epigenomic annotation of gene regulatory alterations during evolution of the primate brain
(a) Schematic of the eight brain regions that were analyzed. Prefrontal Cortex (PFC), Precentral Gyrus (PcGm), Occipital Pole (OP), White Matter (WM), Caudate Nucleus (CN), Thalamic Nuclei (TN), Putamen (Put) and Cerebellum (CB). (b) Anatomical location of the eight regions that were sampled from two chimpanzee brains and three rhesus macaque brains. (c) Hierarchical clustering of 24 human brain samples based on normalized H3K27ac enrichment of 59,786 predicted human CREs. Color bar indicates main anatomical subdivisions. (d) PCA of 24 human brain samples on normalized H3K27ac enrichment of 59,786 human CREs.
