Supplementary Figure 1: Acute Block of Panx1 does not inhibit NMDAR currents.
From: Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity
a) Raw sample traces (data from Figure 2) illustrating the transient NMDAR response. Inward currents were recorded in voltage-clamp in response to 100 μM NMDA. Peak current amplitude was measured as the first peak following the acute NMDAR response. b) Application of antagonists for Panx1, 10panx and TAT-Panx308 did not attenuate the peak inward current compared to their respective inactive controls (SCpanx and TAT-PanxSC) or MK-801 alone.
