Supplementary Figure 4: Detailed results of the social interaction test in the VMAT2DBHcre KO mice.
From: Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons
(a) Ten days of social defeat induce social avoidance in WT and KO mice, however no resilient group was observed in KO mice. Whereas the social interaction time (s) in absence of target was similar between all WT and KO groups, the social interaction time (s) with target was significantly decreased in susceptible WT (n=16) and KO (n=19) mice compared with their respective control (n=24 per control group; F(4,84)=27.5, p<0.001 ; post-hoc ***p<0.001). (b) The social interaction ratio (Target/NoTarget) was significantly decreased in susceptible WT and KO mice compared with their respective control (F(4,83)=12.58, p<0.001; post-hoc ***p<0.001). (c) Whereas the time spent in the corner zone (s) in absence of target was similar between all WT and KO groups, the time spent in the corner zone (s) in presence of the target was significantly increased in susceptible WT and KO mice compared with their respective control (F(4,84)=3.2, p=0.017; post-hoc *p=0.011, **p=0.007).
