Supplementary Figure 6: Chronic reboxetine treatment reverses a susceptible phenotype to social defeat and acute effect of idazoxan on neuronal excitability of the VTA DA system.
From: Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons
(a) After 10 days of social defeat, 1 week treatment with reboxetine (20 mg/kg, i.p.) in susceptible mice counteracted this phenotype to induce a resilient-like phenotype. After 1 week of treatment, the interaction time (s) with the CD1 of the susceptible reboxetine-treated mice (n=8) was significantly increased compared to susceptible NaCl-treated mice (n=15) (F(1,41)=3.95, p=0.05 ; post-hoc *p<0.05, **p=0.0067) and was similar to control groups (NaCl n=15, Reboxetine n=7). (b) The DA neurons firing rate (Hz; right) was not modified after acute idazoxan injection (2 mg/kg, i.p.) compared with baseline (n=7; F(7,57)=1.51, p=0.18, ns). (c) The number of bursts per minute was not modified after acute idazoxan injection (2 mg/kg, i.p.) compared with baseline (F(7,57)=1.13, p=0.36, ns). (d) The percentage of spikes within burst (%SWB) was significantly increased between 25 and 35 minutes after idazoxan injection (2 mg/kg, i.p.) compared to baseline (F(7,57)=4.59, p<0.001, post-hoc *p<0.05 compared with baseline).
