Supplementary Figure 7: dmPFC and BLA directional analysis.

(a) Representative circular distribution of the phase differences between the filtered dmPFC and BLA LFP signals recorded for freezing episodes during Retrieval compared to a control bootstrap simulated phase distribution. (b) Representative dmPFC and BLA LFPs imaginary coherence (Im. coherence, see Methods) for Freezing and No Freezing episodes recorded during Retrieval (shaded areas: mean ± s.e.m.). (c) Representative Granger Causality (GC) analysis performed between dmPFC and BLA LFPs during freezing behaviour. (d) Granger Causality (GC) analyses performed between dmPFC and BLA LFPs during No Freezing periods at retrieval (n = 13 mice). No directional effect was observed in these conditions (b, c) GC analyses performed between dmPFC and BLA LFPs during Freezing (b) and No Freezing (c) periods at Retrieval and for which the phase or amplitude of 4 Hz LFPs was permuted (see Methods). The absence of directional effect in the freezing condition indicates that the direction of interaction between dmPFC and BLA is highly dependent on both 4 Hz phase and amplitude (n = 13 mice). For the representative examples in (a, b, and c), similar results were obtained for the 13 (a, b) and 12 (c) animals used in these experiments.