Supplementary Figure 1: Numbers of significantly associated genes between allelic series knockin heterozygotes versus wild-type mice
From: Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
This figure shows, analogously to Figure 1C, numbers of significantly differentially expressed genes in two-group comparisons between wild type samples and knock-in transgenics with specific Q lengths. No wild type controls were available for cortex and liver at 6 months. This figure demonstrates that (1) the numbers of significantly differentially expressed genes between Q20 samples and WT samples are extremely low, and (2) the trend of the numbers of differentially expressed genes increasing with Q in 6- and 10-month striatum and to a lesser degree in the 10-month cortex is also present in this analysis.
