Supplementary Figure 5: Impaired OL regeneration in Chd7 mutants during remyelination following LPC-induced demyelination
From: Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination
(a) Representative transverse spinal cord sections from LPC-injected mice stained for Sox10 (upper panels) and Olig2 (bottom panels) at 7 and 14 days post lesion (dpl), as indicated. Scale bar, 100 μm.
(b) Quantification of Sox10+ and Olig2+ in LPC lesion sites at dpl 7 and 14 (mean ± SEM; for Sox10 at dpl 7, n = 4 control and 4 mutant, *p = 0.048, t = 2.47; for Sox10 at dpl 14, n = 4 control and 3 mutant, *p = 0.037, t = 2.82; for Olig2 at dpl 7, n = 4 control and 4 mutant, *p = 0.03, t = 2.81; for Olig2 at dpl 14, n = 4 control and 3 mutant, *p = 0.02, t = 3.33; n, number of animals; unpaired two-tailed Student’s t test).
