Supplementary Figure 3: Itga6 is regulated by Yap and Taz with Tead.
From: YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells
(a) H3K27ac ChIP-Seq enrichment profiles in P15 rat sciatic nerve near (i) Itga6 and (ii) Dag1. H3K27ac regions were used to identify the presence of Tead motifs (vertical black bars). (b) ChIP-qPCR analysis on S16 Schwann cells. Enrichments are compared to goat IgG. The negative control site for ChIP-qPCR is a region 17.8 kb from the Tekt3 gene, which is not expressed in Schwann cells. Error bars indicate s.d. n=3 n = 3 independent experiments. Two way ANOVA P < 0.0001 F (2, 42) = 37.94 with Bonferroni post hoc test Sox10 – 20 kb P < 0.0001, Tead1 – 20 kb P < 0.0001, Sox10 – 7.6 kb P = 0.0026, Sox10 + 30 bp P < 0.0001. ** P < 0.01, **** P < 0.0001.
