Supplementary Figure 6: Gene co-expression network modules in spMNs associated with sALS enrich for pathways similar to those enriched in spMN maturation- and age-associates modules (see Fig. 5). | Nature Neuroscience

Supplementary Figure 6: Gene co-expression network modules in spMNs associated with sALS enrich for pathways similar to those enriched in spMN maturation- and age-associates modules (see Fig. 5).

From: ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Supplementary Figure 6

Chow-Ruskey diagrams illustrating the number of overlapping and distinct GO terms enriched in modules identified as significantly correlated or anti-correlated with the sALS component (sALSpos or sALSneg, respectively) and (a) age (AGEpos or AGEneg), (b) spMN maturation (PC1pos or PC1neg), or (c) embryonic spMN development (PC3pos or PC3neg). Pathways are listed in grey boxes extending from the diagrams, along with Bonferroni-corrected P-values of enrichment in sALS modules. For additional information, see Supplementary Tables 2c (for iMN module assignments and properties), 2b, 2d, 2e (for iMN gene set enrichments and P-values), 5c (for sALS module assignments and properties), 5b, 5e, and 5f (for for full lists of significantly enriched gene sets and P-values).

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