Supplementary Figure 1: iPSC-derived MNs resemble fetal rather than adult MNs (see Figs. 1 and 2).
From: ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks
(a) Principal component analysis of 10,605 mRNA transcripts in n = 43 samples. Y-axis depicts sample coordinate along each principal component. The percent contribution to the total variance of the data by each principal component is shown along the x-axis. In order to reduce obscuration, data points are jittered randomly along the x-axis within each bin. The color legend for tissue types is indicated to the left. (b) Regression analysis of linear models generated by using 6 sample traits as predictors and coordinates along 42 principal component as dependent variables. Heat map indicates F-statistic. Bonferroni-corrected P-values thresholds are indicated. Sample coordinates along PC1 to 4 are best explained by tissue type. For additional information, see Supplementary Tables 1a (for sample meta data) and 1b (for linear regression test statistics).
