Supplementary Figure 2: Hdac3 cKO mice exhibit locomotor abnormalities.
From: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior
(a) – (f), Control and Hdac3 cKO mice were subjected to open-field test for 60 minutes and the data was analyzed in 5 minute bins using two-way ANOVA with Bonferroni post hoc. Two-way ANOVA for, (a) vertical activity; Genotype: F(1,44) = 150.1, **** P < 0.0001, Time: F(11, 484) = 18.45, **** P < 0.0001 (Bonferroni post hoc **** P < 0.0001), (b) total distance traveled; Genotype: F(1,44) = 57.18, **** P < 0.0001, Time: F(11, 484) = 47.40, **** P < 0.0001 (Bonferroni post hoc **** P < 0.0001), (c) horizontal activity; Genotype: F(1,44) = 136.26, **** P < 0.0001, Time: F(11, 484) = 38.26, **** P < 0.0001 (Bonferroni post hoc **** P < 0.0001), (d) margin distance traveled Genotype: F(1,44) = 95.66, **** P < 0.0001, Time: F(11, 484) = 63.44, **** P < 0.0001 (Bonferroni post hoc **** P < 0.0001), (e) center distance traveled; Genotype: F(1,44) = 72.76, **** P < 0.0001, Time: F(11, 484) = 5.077, **** P < 0.0001 (Bonferroni post hoc **** P < 0.0001, * P < 0.05), and (f) time spent in the margin; Genotype: F(1,44) = 24.82, **** P < 0.0001, Time: F(11, 484) = 2.131, * P = 0.0171 (Bonferroni post hoc **** P < 0.0001, * P < 0.05); for a-f, n = 22, 24 mice. All values are mean ± s.e.m.
