Supplementary Figure 4: The unpaired context–shock protocol failed to reinstate memory.
From: Infantile amnesia reflects a developmental critical period for hippocampal learning
Experimental schedule is shown above the panel. Acquisition (Acq.) and memory retention are expressed as mean latency ± s.e.m. (in seconds, s). In the unpaired protocol, rats were exposed to the IA context similarly to the trained rats but did not receive a footshock in the dark chamber. They were returned to their home cage and, one hour later, were placed directly onto the grid floor of the dark chamber and immediately shocked (1.0 mA). The unpaired protocol failed to reinstate memory (n=8, 8, Two–way ANOVA followed by Bonferroni post hoc, Condition F(1.56,)=1.901, P=0.1735, Testing F(3,56)=4.720, P=0.0053, Interaction F(3,56)=1.245, P=0.3021; 3 independent experiments). Latency score in Supplementary Table 12.
