Supplementary Figure 1: Performance of P‑Myrf−/− versus P‑Myrf+/− mice on the complex wheel.
From: Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Three weeks after tamoxifen administration at P60-64 or P90-P94 (9), P‑Myrf−/− mice and their P‑Myrf+/− littermates [n=36 (20 males) and 32 (17 males) respectively] were housed singly in cages containing a complex wheel. Average wheel speeds were calculated for each 2-hour time window during the first seven nights (6pm-6am) and plotted as mean ± s.e.m (P‑Myrf−/−, red; P‑Myrf+/−, blue) were analyzed by two-way ANOVA with Bonferroni's post-hoc test. Each night was treated separately for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 10−3, ****p < 10−4
[Night 1: 2 h, p=0.43, t=1.81; 4 h, p=0.029, t=2.83; 6 h, p=0.0089, t=3.20; 8 h, p=0.0044, t=3.40; 10 h, p=0.0017, t=3.66; 12 h, p=0.0036, t=3.46. Night 2: 2 h, p=0.0067, t=3.28; 4 h, p=0.0033, t=3.48; 6 h, p=0.063, t=2.57; 8 h, p=0.016, t=3.03; 10 h, p=0.11, t=2.37; 12 h, p=0.034, t=2.79. Night 3: 2 h, p=0.0019, t=3.63; 4 h, p=0.0041, t=3.43; 6 h, p=0.020, t=2.95; 8 h, p=0.072, t=2.53; 10 h, p>0.99, t=1.05; 12 h, p=0.24, t=2.06. Night 4: 2 h, p=0.020, t=2.96; 4 h, p=0.0010, t=3.80; 6 h, p=0.0007, t=3.90; 8 h, p=0.020, t=2.96; 10 h, p=0.033, t=2.79; 12 h, p=0.30, t=1.96. Night 5: 2 h, p=0.0006, t=3.94; 4 h, p=0.0052, t=3.36; 6 h, p=0.015, t=3.04; 8 h, p=0.13, t=2.32; 10 h, p=0.59, t=1.66; 12 h, p=0.17, t=2.42. Night 6: p<0.0001, t=4.42; 4 h, p<0.0001, t=4.42; 6 h, p<0.0001, t=4.46; 8 h, p=0.0046, t=3.39; 10 h, p=0.020, t=2.96; 12 h, p=0.095, t=2.42. Night 7: 2 h, p<0.0001, t=4.65; 4 h, p<0.0001, t=4.39; 6 h, p=0.0001, t=4.32; 8 h, p=0.0004, t=4.05; 10 h, p=0.20, t=2.13; 12 h, p=0.097, t=2.42. Degrees of freedom=396 throughout.]
