Supplementary Figure 6: Enrichment of dURVs in schizophrenia cases across constrained and unconstrained genes
From: Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
Burden of dURVs across loss-of-function intolerant (LoF-intolerant) genes, missense constrained genes and their complementary sets, stratified across disruptive and damaging URVs. Enrichment and P values were computed using a linear regression model (left panels) and a logistic regression model (right panels) and, contrary to most other analyses in this study, without using exome-wide dURV count to correct for average exome-wide burden. Horizontal bars indicate 95% confidence intervals. As LoF-intolerant and missense constrained genes were defined outside this study, different enrichments observed within and outside these gene sets cannot be attributed to differential false positive rates between cases and controls.
