Supplementary Figure 7: Enrichment of dURVs in schizophrenia cases across gene sets from different tissues
From: Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
Burden of dURVs across 27 tissue expression specific gene sets. Each gene set was generated selecting genes for which expression in a given tissue was at least 5 times the median expression across 27 different human organs and tissues ascertained from 95 individual. Enrichment and P values were computed using a logistic regression model using exome-wide dURV count as a covariate to correct for average exome-wide burden (dot-dashed line). Horizontal bars indicate 95% confidence intervals. Brain specific genes were significantly more enriched for dURVs in schizophrenia cases than the average gene.
