Supplementary Figure 9: Enrichment of dURVs in schizophrenia cases across different X linked intellectual disability gene sets
From: Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
Burden analysis for dURVs across X linked intellectual disability (XLID) genes and developmental disorder genes. X linked ID genes correspond to the union of X linked ID sets of genes as defined from OMIM, GCC, and Chicago. Enrichment was computed separately for males, females, and both groups together. Enrichment and P values were computed using a logistic regression model using exome-wide dURV count as a covariate to correct for average exome-wide burden (dot-dashed line). Horizontal bars indicate 95% confidence intervals. Larger confidence intervals for males reflect the smaller number of variants observed in males due to carrying half as much X chromosome DNA.
