Supplementary Figure 15: Missense predictors comparisons for association with schizophrenia

P values for enrichment of missense URVs classified as damaging by all 256 possible predictors defined as the combination of damaging definitions from any subset of Polyphen2_HDIV, Polyphen2_HVAR, SIFT, LRT, PROVEAN, FATHMM, Mutation Taster, and Mutation Assessor algorithms. P values were computed using a linear regression model and correcting for covariates including total URV count. Predictors including FATHMM performed significantly worse than predictors excluding FATHMM while 25 predictors performed better than the predictor chosen for the analyses in this manuscript (bright red). Both predictors including all algorithms but FATHMM (bright red) and including LRT, MutationTaster, PolyPhen2 HDIV, PolyPhen2 HVAR, and SIFT (green) performed better than each predictor based on a single algorithm.