Supplementary Figure 1: Missense damaging predictions as a function of allele frequency | Nature Neuroscience

Supplementary Figure 1: Missense damaging predictions as a function of allele frequency

From: Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia

Supplementary Figure 1

Percentage of missense variants classified as damaging by eight different classifiers and a classifier consisting of the intersection of classifiers SIFT, PolyPhen-2 HDIV, PolyPhen-2 HVAR, LRT, Mutation Taster, Mutation Assessor, and PROVEAN as a function of minor allele count across 12,332 unrelated individuals from Sweden. Gray and black colors indicate, respectively, variants never observed and variants already observed in the ExAC cohort of 45,376 individuals.

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