Supplementary Figure 7: PLD is upstream of PGE2 in the signaling pathway.
From: Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles
(a) After preconstriction with 200 nM U46619, applying 1 μM PGE2 evokes a dilation. (b) A similar PGE2-evoked dilation was seen in the presence of 1 μM FIPI to block PLD1 and PLD2. (c) Quantification of data from experiments like those in panels a-b, showing that PLD inhibition does not affect the capillary dilation evoked by PGE2. Data shown as mean±s.e.m.
