Supplementary Figure 8: Optical suppression of PV+ and SOM+ interneurons
From: Parallel processing by cortical inhibition enables context-dependent behavior
a, Experimental paradigm. b, Two example cells with whole-cell voltage clamp recording showing loss of context-dependent changes in IPSCs when PV+ interneurons were suppressed. c, Optical suppression of PV+ interneurons reduced context-dependent changes in pyramidal spiking. Summary of cell-attached recordings (n=5 neurons in 3 mice, Spike modulation index (control): 40.3±13.0%, Spike modulation index (opto): 12.8±4.1%, p<0.05, Student’s paired two-tailed t-test). d, Inactivation of SOM+ interneurons also reduced the context dependent spiking of layer 2/3 pyramidal neurons (n=5 neurons, p=0.06, Student’s paired two-tailed t-test).
