Supplementary Figure 1: Function of HSD2 and generation of Hsd11b2Cre mice. | Nature Neuroscience

Supplementary Figure 1: Function of HSD2 and generation of Hsd11b2Cre mice.

From: HSD2 neurons in the hindbrain drive sodium appetite

Supplementary Figure 1

(a) HSD2 converts corticosterone to an inactive form that can no longer compete with aldosterone for the mineralocortioid receptor. (b) Diagram showing: top, the Hsd11b2 gene (5 exons spanning ~5.5 kb with coding region in dark blue). Middle, the targeting vector; Bottom, Hsd11b2 locus after recombination and removal of the frt-flanked SV-40 NeoR selection gene. Some key restriction enzyme sites used for cloning are shown. Diagram is not to scale.

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