Supplementary Figure 4: OB-1 has no effect upon ASIC3-mediated currents nor on stomatin inhibition of ASIC3. | Nature Neuroscience

Supplementary Figure 4: OB-1 has no effect upon ASIC3-mediated currents nor on stomatin inhibition of ASIC3.

From: Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

Supplementary Figure 4

(a) Neither the transient (T), nor sustained (S) phases of pH-evoked currents in CHO cells expressing ASIC3 were inhibited by OB-1 (20 μM). Student’s t-test: P = 0.2452, P = 0.7493; numbers indicate cells recorded (9 Vehicle, 8 OB-1), data are displayed as individual data points and mean peak current density ± s.e.m.. (b) Stomatin inhibits ASIC3-mediated pH gated currents, which is not modulated by OB-1. Student’s t-test, P = 0.4392, P = 0.8650; numbers indicate cells recorded (7 Vehicle, 7 OB-1); data are displayed as individual data points and mean peak current density ± s.e.m..

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