Supplementary Figure 7: CRFR1^PVN-cKO mice are less active then control mice.

(a) Home cage locomotion was assessed for mice placed individually and their locomotion is presented hourly for 72 hrs. (b) Summary of the data. Compared to control mice, CRFR1^PVN-cKO mice are less active during the dark phase (t₍₁₈₎=2, p=0.06) and during the light phase (t₍₁₈₎=2.45, p=0.024). Data presented as means ± SEM. n=10 mice per group. (c,d) CRFR1^PVN-cKO mice are less active following chronic stress. (c) Home cage locomotion was assessed for mice placed individually and their locomotion is presented hourly for 72 hrs. (d) Quantification of the data. Compared to control mice, CRFR1^PVN-cKO mice are less active during the dark phase (t₍₁₁₎=2.40, p=0.035) but not during the light phase (t₍₁₇₎=1.0, n.s). Data presented as mean ± SEM. n=10 (control) and 9 (CRFR1^PVN-cKO) mice per group.