Supplementary Figure 4: Time spent in cocaine-conditioned chamber is correlated with increased cadherin localized to the synaptic membrane at both pre- and postsynaptic compartments of excitatory synapses onto dopaminergic neurons in the VTA.
From: Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning
The percentage of cadherin localized to the synaptic membrane at excitatory synapses onto dopaminergic neurons in the VTA was significantly correlated with time spent in conditioned chamber following cocaine CPP in (a) presynaptic compartments (Linear regression, p<0.05, F(1,10) = 7.351), (b) postsynaptic compartments (Linear regression, p<0.05, F(1,10) = 5.143), and (c) both pre- and postsynaptic compartments analyzed together (Linear regression, p<0.01, F(1,22) = 13.44).
