Supplementary Figure 6: Food CPP does not affect the localization of cadherin and GluA1 at VTA synapses.
From: Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning
(a) Experimental schedule for induction of food CPP. Pairing of palatable food with the conditioned chamber produced robust CPP (p<0.05, significant interaction between genotype and test day, two-way RM ANOVA, F(1,10) = 8.325, *p< 0.05, Bonferroni’s test post hoc, n=6 mice control and palatable food). (b,c) No changes in the distribution of cadherin were observed at (b) excitatory synapses or (c) inhibitory synapses. (d) No redistribution of GluA1 was observed at excitatory synapses onto dopaminergic neurons in the VTA. See also Fig. 2e, h, k ‘Food CPP’ for analysis of relative % of cadherin and GluA1 localized to synaptic membrane. Data shown as mean ± SEM.
