Supplementary Figure 11: Similar impairments of reversed learning by inactivation of LEC–dCA1 transmissions or of postsynaptic dCA1 Calb⁺ cPCs.

(a1−3) The inactivation of (a1) LEC−dCA1, but not (a2) LEC−DG or (a3) MEC−dCA1 transmissions impairs the reverse learning, in which the odor−licking/no n -licking contingencies were reversed, in the days 4−6 with the same mice which underwent the initial learning shown in Fig. 5c−e, respectively. Data were presented as mean±s.e.m. (a4−5) Suppressing Calb⁺ PCs activities in the (a4) dCA1, but not in the (a5) DG impairs the reversal learning in the days 4−6 in the same mice which underwent the initial learning shown in Fig. 5f and g, respectively. Data were presented as mean±s.e.m. (b1−5) Detailed changes of the hit rate (upper) and the correct rejection rate (bottom) for behavioral performance data shown in the Fig. 5c−g and Supplementary Fig. 12a1−5 during the initial and reversal learning, respectively. Statistic differences were presented in the Supplementary Table 4−15. Data were presented as mean±s.e.m.