Supplementary Figure 5: RNA-seq functional subcategories, interaction map of common striatal genes, and table of genes that regulate human striatal maturation and HD differential gene expression. | Nature Neuroscience

Supplementary Figure 5: RNA-seq functional subcategories, interaction map of common striatal genes, and table of genes that regulate human striatal maturation and HD differential gene expression.

From: Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Supplementary Figure 5

(a) RNA-Seq functional subcategories under the super-category nervous system development and function. Select categories listed are predicted to be decreased by calculation of activation z-score. P-value calculated by Fisher’s exact test of expected/observed genes found within specific subcategories. Predicted state of subcategories shows a decrease in neuronal development and function, including: synaptic transmission, long-term potentiation, guidance of axons, and organismal effects to learning and memory. (b) Interaction map: Largest connected Network by Direct Interaction sets in Metacore ® platform, derived from Cluster I in Figure S4. Green lines represent activation red lines inhibition. (c) 1869 DEGs from RNAseq analysis between HD and non-diseased differentiated iPSCs were compared to genes involved in human striatal maturation. Genes relevant to human striatal maturation were also genes predicted to be upstream regulators of the DEGs found in the HD versus non-diseased iPSC-derived samples.

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