Supplementary Figure 7: Endothelial function and vasomotor properties of parenchymal arterioles were unaffected by EC K_IR2.1 knockout.

(A) Typical diameter traces of pressurized parenchymal arterioles from WT (top) and EC K_IR2.1^−/− (bottom) mice. Myogenic tone and responses to the SK and IK channel opener NS309 were essentially identical between groups. (B) Summary of myogenic tone at 40 mm Hg intravascular pressure (top) and dilation evoked by NS309 (bottom) in WT and EC K_IR2.1^−/− mice (WT, n = 7 mice; EC K_IR2.1^−/−, n = 9 mice); tone: P = 0.2580, (t₁₃ = 1.183); NS309: P = 0.7969, (t₁₃ = 0.2627); unpaired Student’s t-test). All error bars represent s.e.m.