Supplementary Figure 3: SK and IK channel activation in pial artery ECs.
From: Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
(A) Typical experiment in a pial artery EC in which a small inwardly rectifying current (black line) is observed in response to a 200-ms ramp from -140 to +50 mV under control conditions (6 mM [K+]o, 300 nM [Ca2+]i). Subsequent application of 1 μM NS309 (green) produced large SK and IK currents. (B) Typical experiment in a pial artery EC dialyzed with 3 μM Ca2+, which caused the immediate development of prominent K+ currents.
