Supplementary Figure 3: Ex-4 dose not alter food responding.

(a) Graphical representation of food responding procedure, showing mouse in operant chamber permitted to respond for food pellets (20 mg). Animals respond on an active lever for food rewards according to a FR5TO20 reinforcement schedule. Each reward earned is delivered into a central food dispenser and triggers the activation of a cue light located above the active lever for 20 sec. Responding on the inactive lever has no scheduled consequence. (b) Mean (± s.e.m.) number of food rewards earned by mice after Ex-4 (10 μg/kg) administration.