Supplementary Figure 5: Graphical abstract of context-dependent microglial renewal and clonal expansion.
From: A new fate mapping system reveals context-dependent random or clonal expansion of microglia
Microglial renewal occurs randomly and steadily throughout the healthy CNS with regional differences in rate. The onset of neurodegeneration triggers rapid clonal expansion and activation of microglial cells. During recovery the altered microglial network gradually returns to homeostatic cell density and a non-activated state. Excess microglia associated with disease are eliminated via cell egress and local apoptotic cell death to regain steady state microglial interfaces in the CNS.
