Supplementary Figure 4: Microvascular pathology during cerebral ischemia | Nature Neuroscience

Supplementary Figure 4: Microvascular pathology during cerebral ischemia

From: A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging

Supplementary Figure 4

(a) Schematic showing timeline and approach for in vivo imaging during transient cerebral ischemia.

(b-d) In vivo time-lapse sequences captured from the cerebral cortex showing collapse and reperfusion of SMC-covered (arrows) (SMA-mCherry+) but no change in diameter in pericyte-covered (NeuroTrace+) vessels.

(e) Percent changes in diameter from baseline in SMC and pericyte covered vessels showing significant vessel collapse/constriction during ischemia only on SMC-covered vessels (pericyte covered: 28 vessel locations, SMC covered: 23 vessel locations from n=3 mice, unpaired two-tailed student’s t-test p values as indicated during: t=6.244279 df=4, after: t=1.104133 df=4).

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