Supplementary Figure 13: Effect of HA-caIKK-β on MK801-induced hyperlocomotor activity in Hdac2-cKO and control mice
From: Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects
(a,b) AAV-mediated over-expression of HA-caIKK-β increases hyperlocomotor activity induced by the dissociative drug MK801 (0.3 mg/kg) in control mice (n = 4-12 mice per experimental condition), but not in HDAC2-cKO littermates (n = 4-11 mice per experimental condition). Time course of MK801-induced locomotion measured in 5-min blocks (time of injection is indicated by arrows; see also Fig. 8b,c).
