Supplementary Figure 1: HDAC2 immunoreactive levels after chronic antipsychotic treatment in mouse frontal cortex
From: Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects
(a,b) HDAC2 immunoreactivity levels in CaMKIIα-positive (a) and PV-positive (b) neurons in mouse frontal cortex after chronic treatment with clozapine, risperidone or haloperidol. Mice were treated chronically (21 days) with clozapine (10 mg/kg), risperidone (4 mg/kg), or haloperidol (1 mg/kg), or vehicle, and sacrificed one day after the last injection. See also Fig. 1d,e for high-magnification images and Fig. 1f,g for quantitative assessment. Nuclei were stained in blue with DAPI. Scale bars, 20 μm (a,b).
