Supplementary Figure 4: Effect of hidden confound removal.
From: An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
Number of features (genes, methylation probes, histone peaks) associated with significant xQTLs vs. the number of PCs (hidden confounds) shown. The optimal number of PCs to account for was 10 for all three -omic data types. To avoid overfitting, this analysis was only performed on features that reside on chromosome 18.
