Supplementary Figure 4: Comparison of lifetime place coding and place cell metrics between Df(16)A+/− and WT mice.
From: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
a. Lifetime place coding percentage, the fraction of ROIs that were ever identified as a place cell by the nth session imaged (lifetime place coding, Cox Regression, B=0.222, p=0.244). b. Fraction of all sessions imaged that an ROI was identified as a place cell (fraction of sessions a place cell; WT: 0.254 ± 0.004, n=3162 cells; Df(16)A±: 0.214 ± 0.004, n=3322 cells; Mann-Whitney U, U=4.55x106, p<0.0001), averaged within mice (inset; independent sample T-test, t=1.517, p=0.164). c. Transient sensitivity, defined as the fraction of laps in which a transient occurred in the place field (WT: 0.5786 ± 0.00218, n=12524 place cell*sessions; Df(16)A±: 0.5445 ± 0.0027, n=7664 place cell*sessions; Mann-Whitney U, U=4.4x107, p<0.0001), averaged within mice (inset, independent samples T-test, t=0.0142, p=0.989). d. Transient specificity, defined as the fraction of transients that occurred in the place field (WT: 0.795 ± 0.0161, n=12571 place cell*sessions; Df(16)A±: 0.872 ± 0.0018, n=7683 place cell*sessions; Mann-Whitney U, U=3.59x107, p<0.0001), averaged within mice (inset; Welch’s T-test, t=2.427, p=0.0544). e. Place field width (WT: 32.09 ± 0.125, n=14833 place fields; Df(16)A±: 29.25 ± 0.136, n=8529 place fields; Mann-Whitney U, U=5.5x107 p<0.0001), averaged within mice (inset, Welch’s T-test, t=1.990, p=0.0911). f. Single-cell sparsity (WT: 0.2325 ± 0.001, n=12571 ROI*sessions; Df(16)A+/: 0.186 ± 0.001, n=8683 ROI*sessions; Mann-Whitney U, U=3.35x107, p<0.0001), averaged within mice (inset, Welch’s T-test, t=2.064, p=0.0852). ***p<0.001.
