Supplementary Figure 7: Impaired task performance during CA1 inactivation.
From: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
During initial learning of a reward location, local inactivation of CA1 lead to significantly reduced task performance (Days 1-3, muscimol to saline vs. saline to muscimol: Mann-Whitney U, U=126.5, p<0.0001). In addition, mice which received saline infusion during the first three initial learning days performed significantly worse on the fourth day when they were infused with muscimol (saline to muscimol, Days 1-3: 0.221 ± 0.053, n=36 sessions; Day 4: 0.084 ± 0.034, n=12 sessions; Mann-Whitney U, U=111, p=0.0235) and now performed at a similar level to mice which were initially infused with muscimol (Day 4, saline to muscimol vs. muscimol to saline: independent samples T-test, t=0.633, p=0.535).
