Supplementary Figure 9: Sharp wave-ripples (SWR) are altered in Df(16)A+/– mice.
From: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
a. Mean SWR wavelet power for WT (left) and Df(16)A± (right) mice. b. Difference (Df(16)A± - WT) of mean SWR wavelet power in a. c. Rate of SWRs during stationary bouts (mean ± SD; WT: 0.106 ± 0.103, n=45 stationary intervals; Df(16)A±: 0.178 ± 0.120, n=61 stationary intervals; Wilcoxon rank-sum test, h=3777.5, p=0.00096). d. Mean wavelet power (mean ± SD; WT: 3.622 ± 1.133, n=145 sharp wave-ripples; Df(16)A±: 4.060 ± 0.838, n=357 sharp wave-ripples; Wilcoxon rank-sum test, h=98423, p<0.0001). e. Frequency with maximum power (mean ± SD; WT: 152.190 ± 17.174, n=145 sharp wave-ripples; Df(16)A±: 163.391 ± 29.485, n=357 sharp wave-ripples; Wilcoxon rank-sum test, h=94798, p=0.00066). f-h. Same as (c-e) for several SWR detection thresholds (significance by Wilcoxon rank-sum test as marked). *p<0.05, **p<0.001, ***p<0.0001. SWR-related place cell reactivation (for example, as in Wilson and McNaughton, Science, 1994; Lee and Wilson, Neuron, 2002; Foster and Wilson, Nature 2006) was not directly assessed.
