Supplementary Figure 4: Loss of striatal dopamine in A53T mice cannot be accounted for by formation of dopamine-protein adducts. | Nature Neuroscience

Supplementary Figure 4: Loss of striatal dopamine in A53T mice cannot be accounted for by formation of dopamine-protein adducts.

From: Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

Supplementary Figure 4

(a) Triton-soluble (S) and insoluble (P) extracts of striatal tissue from mice at 2.5 or 5 mpi were analyzed by SDS-PAGE and near-infrared fluorescence (nIRF). (b) Total levels of dopamine-protein adduct (combined soluble and insoluble nIRF signal) did not change either between injection groups or within groups over time. (n = 3 mice per group, F(3,8) = 1.763; one-way ANOVA with Tukey’s correction for multiple comparisons). Box plots show median, 25th and 75th percentiles, minimum and maximum values.

Back to article page