Supplementary Figure 4: Quantitative differences in LC neuronal responses to aversive shocks vs. sensory predictive cues. | Nature Neuroscience

Supplementary Figure 4: Quantitative differences in LC neuronal responses to aversive shocks vs. sensory predictive cues.

From: Modular organization of the brainstem noradrenaline system coordinates opposing learning states

Supplementary Figure 4

(a) Shock evoked responses do not differ between fear (‘Fear’ and ‘‘Fear+Extinction’ cells) and ‘Extinction’ neurons (t18 = 0.66, P = 0.52, unpaired t-test). Data represent the mean ± SEM. (b) Shock USs activate a significantly larger proportion of LC neurons compared with tone CSs presented during pre-CS, early and late extinction (Cochran’s Q test χ2(3)=37.17, P<0.0001, followed by Wilcoxon sign tests for individual comparisons ****P<0.0001, ***P<0.001, *P<0.05). (c) Shocks evoke a significantly larger response compared with auditory CS-evoked responses in LC neurons (t36 = 4.50, * P < 0.0001).

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