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PI-3 kinase and IP3: partners in NT3-induced synaptic transmission

Nature Neuroscience volume 4, pages 5–7 (2001)Cite this article

Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.

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Figure 1: Neurotrophins bind to and stimulate the activity of their receptors, the Trk tyrosine kinases.

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Authors and Affiliations

  1. Brain Tumor Research Center, Montreal Neurological Institute,

    David R. Kaplan

  2. Department of Physiology, McGill University, Montreal, H3A 2B4, Quebec, Canada

    Ellis Cooper

Authors
  1. David R. Kaplan
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  2. Ellis Cooper
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Kaplan, D., Cooper, E. PI-3 kinase and IP3: partners in NT3-induced synaptic transmission. Nat Neurosci 4, 5–7 (2001). https://doi.org/10.1038/82897

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