Figure 1: Effects of MAFP on DSI in hippocampal CA1 pyramidal cells.
From: Erratum: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Top, traces from a representative experiment showing the effects of vehicle (ethanol, 0.00003%) or MAFP (Tocris, 45 nM) on the transient reduction of spontaneous inhibitory postsynaptic potentials (IPSCs) elicited by a depolarizing stimulus (arrow). Scale bars, 100 pA, 5 s. Bottom left, averaged time-course of DSI after administration of vehicle (solid squares) or MAFP (open squares). Bottom right, DSI area in the first 30 s after stimulus application was significantly larger in MAFP-treated than in control slices.
