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Dnmt3a: addiction's molecular forget-me-not?

A new study examines the contribution of DNA methylation to long-term behavioral and morphological changes produced by cocaine exposure or chronic social defeat stress.

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Figure 1: Increased expression of Dnmt3a in the NAc enhances the density of thin spines and impairs emotional regulation.

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Correspondence to F Woodward Hopf.

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Hopf, F., Bonci, A. Dnmt3a: addiction's molecular forget-me-not?. Nat Neurosci 13, 1041–1043 (2010). https://doi.org/10.1038/nn0910-1041

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