Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Long-distance signaling via presynaptic glutamate transporters

Nature Neuroscience volume 9, pages 1352–1353 (2006)Cite this article

Glutamate transporters have long been thought to help terminate the synaptic response through neurotransmitter binding and reuptake, but a new report in this issue identifies a role for their anionic current in information transmission in the retina.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bipolar cells communicate with each other via glutamate spillover.

Lori Vaskalis

References

  1. Fairman, W.A., Vandenberg, R.J., Arriza, J.L., Kavanaugh, M.P. & Amara, S.G. Nature 375, 599–603 (1995).

    Article  CAS  Google Scholar 

  2. Wadiche, J.I., Amara, S.G. & Kavanaugh, M.P. Neuron 15, 721–728 (1995).

    Article  CAS  Google Scholar 

  3. Arriza, J.L., Eliasof, S., Kavanaugh, M.P. & Amara, S.G. Proc. Natl. Acad. Sci. USA 94, 4155–4160 (1997).

    Article  CAS  Google Scholar 

  4. Brasnjo, G. & Otis, T.S. Neuron 31, 607–616 (2001).

    Article  CAS  Google Scholar 

  5. Wadiche, J.I. & Jahr, C.E. Nat. Neurosci. 8, 1329–1334 (2005).

    Article  CAS  Google Scholar 

  6. Sarantis, M., Everett, K. & Attwell, D. Nature 332, 451–453 (1988).

    Article  CAS  Google Scholar 

  7. Picaud, S.A., Larsson, H.P., Grant, G.B., Lecar, H. & Werblin, F.S. J. Neurophysiol. 74, 1760–1771 (1995).

    Article  CAS  Google Scholar 

  8. Hasegawa, J., Obara, T., Tanaka, K. & Tachibana, M. Neuron 50, 63–74 (2006).

    Article  CAS  Google Scholar 

  9. Veruki, M.L., Morkve, S.H. & Harveit, E. Nat. Neurosci. 9, 1388–1396 (2006).

    Article  CAS  Google Scholar 

  10. Fremeau, R.T. Jr., Voglmaier, S., Seal, R.P. & Edwards, R.H. Trends Neurosci. 27, 98–103 (2004).

    Article  CAS  Google Scholar 

  11. Palmer, M.J., Taschenberger, H., Hull, C., Tremere, L. & von Gersdorff, H. J. Neurosci. 23, 4831–4841 (2003).

    Article  CAS  Google Scholar 

  12. Wersinger, E. et al. J. Physiol. (Lond.) advance online publication 14 September 2006 (doi:10.1113/jphysiol.2006.118281).

  13. Zenisek, D., Davila, V., Wan, L. & Almers, W. J. Neurosci. 23, 2538–2548 (2003).

    Article  CAS  Google Scholar 

  14. Pow, D.V. & Barnett, N.L. Cell Tissue Res. 297, 57–66 (1999).

    Article  CAS  Google Scholar 

  15. Ingram, S.L., Prasad, B.M. & Amara, S.G. Nat. Neurosci. 5, 971–978 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA

    Jacques I Wadiche

  2. Vollum Institute, Oregon Health and Science University, Portland, 97239, Oregon, USA

    Henrique von Gersdorff

Authors
  1. Jacques I Wadiche
    View author publications

    Search author on:PubMed Google Scholar

  2. Henrique von Gersdorff
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wadiche, J., von Gersdorff, H. Long-distance signaling via presynaptic glutamate transporters. Nat Neurosci 9, 1352–1353 (2006). https://doi.org/10.1038/nn1106-1352

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nn1106-1352

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing