Figure 1: Antagonism of GLUK5-containing kainate receptors suppresses kainate-induced disinhibition in the hippocampus. | Nature Neuroscience

Figure 1: Antagonism of GLUK5-containing kainate receptors suppresses kainate-induced disinhibition in the hippocampus.

From: Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures

Figure 1

Field potential recordings from stratum pyramidale of area CA1 to illustrate the population effect of kainate-induced disinhibition and its antagonism by pre-treatment with LY377770. The graphs plot the mean ± s.e.m. amplitude of the primary (black circle) and secondary (white circle) population spikes versus stimulus intensity, for eight experiments. The traces are averages of four successive responses, evoked by a stimulus intensity of 15 V, from one representative experiment.

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