Figure 5: GLUK5 receptor antagonists prevent focally evoked pilocarpine-induced limbic seizures and accompanying rises in extracellular (EC) glutamate and GABA concentrations in conscious rats.
From: Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures
(a) Data are presented as in Fig. 4 for 6 similar experiments where the rats were pretreated with LY377770 (30 mg/kg, i.p.). Electrocorticographic recordings and dialysate concentrations of glutamate and GABA (in percent of baseline levels) during baseline (i), after i.p. injection with LY377770 (ii), 20–40 min (iii) and 80–100 min after ending pilocarpine perfusion (iv). (b) Equivalent data for six animals pretreated with LY382884 (150 mg/kg).
