Figure 4
From: Defining molecular basis for longevity traits in natural yeast isolates
Mitochondrial respiratory composition varies across the strains according to lifespan. (a) Mean replicative lifespan of strains. Strains are ordered according to their mean lifespan (see also Figure 1b). (b) Levels of certain proteins correlate with lifespan. The mean values of the selected proteins (related to mitochondrial function) are shown. For each protein, the levels were standardized by setting mean=0 and s.d.=1 across the strains. The patterns of DBPVG1373, YJM981, YJM975, and Y12 strains showed different patterns. See Supplementary Table 2 for more detail. (c) Effect of growth on a respiratory substrate on lifespan. Replicative lifespan of 10 strains was tested on yeast peptone glycerol (3% YPG) plates and expressed as mean (left) and maximum (right) replicative lifespan. Except for the three long-lived outlier strains (YJM981, YJM975, and Y12), all strains either increased or did not change lifespan when their growth substrate was switched from glucose to glycerol.
