Figure 1
From: Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function
Effect of ACE2 deficiency on cognitive function and cerebral blood flow. (a) Cognitive function was assessed using the Morris water maze as described in Materials and methods. Data are expressed as mean±s.e.m. (n=18–23 for each group). *P<0.05 versus WT mice. (b) Cognitive function was assessed using Y maze test as described in Materials and methods. Data are expressed as mean±s.e.m. (n=11–12 for each group). *P<0.05 versus WT mice. (c) Cerebral blood flow was measured with a laser speckle blood flow imager as described in Materials and methods. Representative images of each group are shown in the upper panels, and quantitative analysis is shown in the lower panel. The value in each mouse was determined as the average of 10 image pixels. Data are expressed as mean±s.e.m. (n=9–10 for each group). ACE2, angiotensin-converting enzyme 2; WT, wild type.
