Figure 6
From: Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function
Effect of Ang-(1–7) and telmisartan on ACE2-deficient mice. (a) Cognitive function was analyzed using Morris water maze test as described in Materials and methods. Ang-(1–7) was administered intraperitoneally using osmotic minipump at the concentration of 0.5 mg/kg/day. Data are expressed as mean±s.e.m. (n=5–8 for each group). *P<0.05 versus vehicle group. (b) Cognitive function was analyzed using Morris water maze test as described in Materials and methods. Telmisartan was administered in drinking water at the concentration of 1.0 mg/kg/day. Values are expressed as mean±s.e.m. (n=16 for each group). *P<0.05 versus vehicle group. (c) Effect of Ang-(1–7) and telmisartan on cognitive function in WT mice. Data are expressed as mean±s.e.m. (n=15–30 for each group). *P<0.05 versus vehicle group. ACE2, angiotensin-converting enzyme 2; WT, wild type.
