Figure 8
From: Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function
Effect of antioxidant tempol on cognitive function in ACE2-deficient mice. (a) Cognitive function was evaluated using Morris water maze test as described in Materials and methods. Tempol was injected intraperitoneally once a day for 2 weeks at the concentration of 100 mg/kg/day. Data are expressed as mean±s.e.m. (n=7–18 for each group). *P<0.05 versus vehicle group. (b) Cerebral blood flow was measured with a laser speckle blood flow imager as described in Materials and methods. Representative images of each group are shown in the upper panels, and quantitative analysis is shown in the lower panel. The value in each mouse was determined as the average of 10 image pixels. Data are expressed as mean±s.e.m. (n=7–9 for each group). *P<0.05 versus vehicle group. ACE2, angiotensin-converting enzyme 2.
